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Berberine Complex

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Berberine is a constituent of some plants including Barberry (Berberis vulgaris), Oregon Grape (Berberis aquifolium), and Goldenseal (Hydrastis canadensis). Berberine Complex contains extracts of berberine-containing plants: barberry, Oregon grape, and goldenseal. In addition to berberine, Goldenseal extract also contains other alkaloids such as hydrastine. Traditional use of herbs and extracts often rely on the complex nature of plants rather than isolated bioactive compounds. Berberine Complex is intended for traditional gastrointestinal support.


Goldenseal, which contains alkaloids including berberine, has been traditionally used in North American for gastrointestinal support. Mechanistic studies in animals and cell culture models suggest berberine may modulate gut microbiota by binding to DNA of bacteria.

In animal and cell culture studies, berberine has demonstrated an ability to support the intestinal microenvironment. In a human Caco-2 cell model, berberine exhibited an ability to maintain tight junctions and support epithelial barrier function.

Serving Size: 2 Capsules

Servings Per Container: 45

  • Total Carbohydrate <1 g <1%†
  • Barberry (Berberis vulgaris) (root) Extract 400 mg **
  • Oregon Grape (Berberis aquifolium) (root and stem) Extract 400 mg **
  • Goldenseal (Hydrastis canadensis) (root and rhizome) Extract standardized to contain 5% total alkaloids including berberine and hydrastine 100 mg **

** Daily Value (DV) not established

†Percent daily value is based on a 2000 calorie diet

Other Ingredients: plant-derived capsule (hypromellose), cellulose, magnesium stearate, silica.

Adults take 2 capsules three times daily, or as recommended by a healthcare professional.

Do not use this product if you are pregnant or nursing.

If you have diabetes or if you are taking prescription drugs, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed.

Store at room temperature. Avoid excessive heat and direct sunlight.