The Synergistic Combination of PEA & Luteolin

When combined, PEA and luteolin show enhanced anti-inflammatory, anti-oxidant and neuroprotective properties. Coadministration of PEA with luteolin has been shown to decrease mast cell activation significantly more than PEA or luteolin alone. This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.* (Impellizzeri 2018)

Side Effect Free

PEA occurs naturally in the body and in many foods. No side effects have been reported with its use, even at the highest doses. (Gabrielsson 2016)

The recommended daily dose of Mirica® is equivalent to the amount of luteolin found in one artichoke. At this dose luteolin is safe and no side effects have been reported.